Product Name: Pikamilone
Product Categories: Heterocycles;Chemistry;API;Other APIs
Appearance Crystal powder
Application Smart nutrition
Picamilon is a dietary supplement and nootropic drug. It is a
combination of Vitamin B3, also known as niacin, and the
neurotransmitter GABA. This supplement is taken orally, typically
in powder or tablet form, and is able to cross the blood-brain
barrier. Once in the brain, it is hydrolyzed into GABA and niacin.
The function of picamilon is two-fold, since, when the compound is
broken down into its constituent parts in the brain, each one has a
different effect. Niacin acts as a vasodilator, which enlarges the
blood vessels of the brain. This, in turn, leads to increased blood
flow, reduced blood pressure, and is thought to assist in the
management of migraine headache pain.
When the second part of the picamilon compound, GABA, is activated
in the brain, it is a believed to create a moderate anti-anxiety
effect. This is known as an anxiolytic response, and is due to that
fact that GABA is an inhibitory neurotransmitter. GABA limits,
rather than encourages, certain brain functions.
The primary Nootropic benefits of Picamilon center on mood boosting
and overall brain function improvements. This includes helping to reduce feelings of stress and anxiety.
In fact, many users feel that Picamilon is so good at reducing
these feelings that they use Picamilon on a regular basis to help
relax. An improved positive outlook and attitude will also often
follow. Once a person is relaxed, they will usually find themselves
having improved sleep which is also more restful and deeper.
As a brain booster, Picamilon benefits also include better mental
energy and improved clarity and focus. It is easier to think and
make decisions as well when using Picamilon supplements.
There are also a number of additional health benefits associated
with daily dosages of Picamilon nootropic. For starters, Picamilon
helps to reduce and regulate blood pressure in the body. There is
also a lot of evidence demonstrating that it can alleviate
migraines and poor cerebral blood flow and circulation.
This supplement has further been shown to treat the symptoms of
acute alcohol intoxication and the effects upon the brain. There is
even the possibility that Picamilon may act as an anti-oxidant and rid the brain of toxins and other harmful substances.
It is helpful to think of Picamilon as a mixture of two different
chemicals – GABA and Niacin.
Once it is absorbed into the bloodstream both compounds cross over
the blood-brain barrier together. This is courtesy of the Niacin
pathways since GABA is not capable of this action by itself.
As the GABA enters into the central nervous system it targets
receptor sites and performs its job as the chief inhibitory
neurotransmitter within the human body. GABA is known to prevent over-stimulation and excitotoxicity of your brain cells which can occur when your
neurons are firing faster than they should be.
We experience this over-activity as anxiety and the feeling like
you cannot stop thinking about certain memories or future
possibilities. Picamilon essentially curbs these excessive thought
processes, resulting in a sensation of peace and calm.
Many people are tempted to think of the Niacin found in Picamilon
powder simply as a GABA transport method. They would be incorrect;
the Niacin from Picamilon is itself active and has a positive nootropic effect on mental performance. This substance is primarily responsible for opening up (or
dilating) blood vessels within the brain.
As these passageways open, this leads to the improvement in
cerebral blood flow, oxygen supply and glucose metabolism. The
result is better cellular energy and improved resource supply to
maintain the health of your neurons.
It also helps to keep skin healthy and may even play a role in
improving vision in those suffering from glaucoma.
The standard dosage range for Picamilon is between 50 and 300 mg
per day.Of course, this may be split into several different
administrations throughout the day, depending upon how it effects
the user. Generally, a divided dose means one in the morning and
one in the evening.
Most supplements sell it in 150 mg tablets or capsules, but you can also buy it as a bulk powder to get more control over
your dosages. Picamilon works best when taken on an empty stomach
and the effects of this nootropic will last anywhere from two to
You should always start out with the smallest effective Picamilon
dose possible. Study the benefits obtained and then determine if
increasing the dose is in order.
Stacking & Cycling Picamilon
Many users have found that stacking and cycling their Picamilon
dosages can be very effective. It is certainly very safe and it may
even help to increase the effects of other Nootropic supplements
like the Racetams including Aniracetam and Piracetam. Even herbs like Valerian Root and Kava can be helpful when used in
There are a number of other Nootropics that have similar effects to
Picamilon, but might lead to tolerance if used on a daily basis.
This means that it might be helpful to include Picamilon as part of
a cycle with something like, say, Phenibut.
Start with the safer option (Picamilon) and use on a 3 or 4 day on
and 2 day off cycle. For the days off of Picamilon, substitute with the Phenibut.
|Pramiracetam||Choline Bitartrate||Memantine HCL|
|Oxiracetam||Coluracetam(MKC 231)||PRL-8-53 HCL|
|Pikamilone sodium salt||Fladrafinil||Rivastigmine|
|2-Dimethylaminoethanol (+)-bitartrate salt/DMAE/ L-Bitartrate||Hordenine HCl||Sulbutiamine|
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1. Legal status in the United States
Adrafinil is easily available from supplement shops in the USA
while Modafinil requires a prescription. That’s to say, adrafinil,
unlike Modafinil, is not regulated in the United States of America
and may privately be purchased without the need of a doctor’s
2. Side effects comparison
The side effects of Modafinil are similar to those listed for
Adrafinil. Here we discover that Modafinil is far safer than
Adrafinil for in a long period. The explanation for this is simple
that Modafinil is not metabolized in the liver in the same way that
Adrafinil is. Actually, when Adrafinil reaches your liver, the
enzymes present actually convert this drug into Modafinil. It is
this conversion process which puts stress on the organ and may lead
to hepatoxicity. Because Modafinil does not get converted in the
same manner, it does not come with the same risk of side effects.
Consequently, Modafinil may be safer than Adrafinil in the long
3. Potency and speed
Adrafinil is first metabolized into modafinil in the liver.
However, the metabolite takes around thirty minutes to one hour to
accumulate to active levels in the bloodstream when taken orally
before eating anything. Because of the additional processing,
Adrafinil takes longer time to take effect than Modafinil.
Aniracetam is a Nootropic supplement which was developed in the
1970’s by the Hoffman-La Roche
(Belgium) company. This supplement is also part of a class known as
Racetams, which are particularly
noted for their ability to help increase and improve a number of
cognitive processes. Aniracetam also
exhibits anxiolytic properties and enhances mood alongside memory
and focus. This supplement has
been well-studied for a number of years and is known to be
generally very well-tolerated with minor side
effects and a very low level of toxicity. However, before embarking
on a supplementation program with
Aniracetam powder it can be helpful to understand what the benefits
are, how this supplement actually
works, potential stacks, side effects, etc.
The main benefits of Aniracetam are related to improved mental
performance. This includes an increase
in memory and possibly even enhanced learning capacity. This may
actually occur differently in each
person; some will see strong effects and begin remembering
everything while others may just simply begin remembering small and subtle details.